Biological properties of surface modified 316 LVM steel

Abstract This paper aimed to investigate the selected physicochemical and biological properties of titanium dioxide thin films deposited by atomic layer deposition on 316LVM stainless steel dedicated for cardiovascular implants. The main challenge in surface modification these implants is complexity processes taking place circulatory system. was carried out a number cycles 500 temperature 200 °C substrate. topography microstructure were examined. Mouse fibroblasts L929 Human Dermal Fibroblasts (NHDF-Ad) used cytotoxicity assays. following biocompatibility aspects investigated vitro: direct cytotoxicity, hemolysis, platelet activation aggregation, pro-inflammatory cytokine levels. inherited substrate topography. amorphous with typical growth. film improved vitro cell response terms viability. cells also able proliferate adhere; however, differences morphology distribution nuclei observed. host damage not noted lactate dehydrogenase proposed reduced hemolysis index did significantly affect aggregation. Acute predicted basing assay. results tests may be basis further assessment proving full specific